Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats.
Identifieur interne : 000648 ( 2020/Analysis ); précédent : 000647; suivant : 000649Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats.
Auteurs : Marco Malavolta [Italie] ; Robertina Giacconi [Italie] ; Dario Brunetti [Italie] ; Mauro Provinciali [Italie] ; Fabrizio Maggi [Italie]Source :
- Cells [ 2073-4409 ] ; 2020.
Descripteurs français
- KwdFr :
- Anti-infectieux (normes), Anti-infectieux (usage thérapeutique), Azithromycine (usage thérapeutique), Humains, Infections à coronavirus (immunologie), Infections à coronavirus (traitement médicamenteux), Interleukine-6 (immunologie), Pandémies, Pneumopathie virale (immunologie), Pneumopathie virale (traitement médicamenteux), Pyrazoles (usage thérapeutique), Santé mondiale (tendances), Vieillissement (immunologie).
- MESH :
- immunologie : Infections à coronavirus, Interleukine-6, Pneumopathie virale, Vieillissement.
- normes : Anti-infectieux.
- tendances : Santé mondiale.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Anti-infectieux, Azithromycine, Pyrazoles.
- Humains, Pandémies.
English descriptors
- KwdEn :
- Aging (immunology), Anti-Infective Agents (standards), Anti-Infective Agents (therapeutic use), Azithromycin (therapeutic use), Cellular Senescence (immunology), Coronavirus Infections (drug therapy), Coronavirus Infections (immunology), Global Health (trends), Humans, Interleukin-6 (immunology), Pandemics, Pneumonia, Viral (drug therapy), Pneumonia, Viral (immunology), Pyrazoles (therapeutic use).
- MESH :
- chemical , immunology : Interleukin-6.
- chemical , standards : Anti-Infective Agents.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- immunology : Aging, Cellular Senescence, Coronavirus Infections, Pneumonia, Viral.
- chemical , therapeutic use : Anti-Infective Agents, Azithromycin, Pyrazoles.
- trends : Global Health.
- Humans, Pandemics.
Abstract
The higher death rate caused by COVID-19 in older people, especially those with comorbidities, is a challenge for biomedical aging research. Here we explore the idea that an exacerbated inflammatory response, in particular that mediated by IL-6, may drive the deleterious consequences of the infection. Data shows that other RNA viruses, such as influenza virus, can display enhanced replication efficiency in senescent cells, suggesting that the accumulation of senescent cells with aging and age-related diseases may play a role in this phenomenon. However, at present, we are completely unaware of the response to SARS-CoV and SARS-COV-2 occurring in senescent cells. We deem that this is a priority area of research because it could lead to the development of several therapeutic strategies based on senotherapeutics or prevent unsuccessful attempts. Two of these senotherapeutics, azithromycin and ruxolitinib, are currently undergoing testing for their efficacy in treating COVID-19. The potential of these strategies is not only for ameliorating the consequences of the current emergence of SARS-CoV-2, but also for the future emergence of new viruses or mutated ones for which we are completely unprepared and for which no vaccines are available.
DOI: 10.3390/cells9040909
PubMed: 32276453
Affiliations:
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pubmed:32276453Le document en format XML
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Here we explore the idea that an exacerbated inflammatory response, in particular that mediated by IL-6, may drive the deleterious consequences of the infection. Data shows that other RNA viruses, such as influenza virus, can display enhanced replication efficiency in senescent cells, suggesting that the accumulation of senescent cells with aging and age-related diseases may play a role in this phenomenon. However, at present, we are completely unaware of the response to SARS-CoV and SARS-COV-2 occurring in senescent cells. We deem that this is a priority area of research because it could lead to the development of several therapeutic strategies based on senotherapeutics or prevent unsuccessful attempts. Two of these senotherapeutics, azithromycin and ruxolitinib, are currently undergoing testing for their efficacy in treating COVID-19. The potential of these strategies is not only for ameliorating the consequences of the current emergence of SARS-CoV-2, but also for the future emergence of new viruses or mutated ones for which we are completely unprepared and for which no vaccines are available.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li><li>Toscane</li></region><settlement><li>Milan</li><li>Pise</li></settlement><orgName><li>Université de Pise</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Malavolta, Marco" sort="Malavolta, Marco" uniqKey="Malavolta M" first="Marco" last="Malavolta">Marco Malavolta</name></noRegion><name sortKey="Brunetti, Dario" sort="Brunetti, Dario" uniqKey="Brunetti D" first="Dario" last="Brunetti">Dario Brunetti</name><name sortKey="Giacconi, Robertina" sort="Giacconi, Robertina" uniqKey="Giacconi R" first="Robertina" last="Giacconi">Robertina Giacconi</name><name sortKey="Maggi, Fabrizio" sort="Maggi, Fabrizio" uniqKey="Maggi F" first="Fabrizio" last="Maggi">Fabrizio Maggi</name><name sortKey="Provinciali, Mauro" sort="Provinciali, Mauro" uniqKey="Provinciali M" first="Mauro" last="Provinciali">Mauro Provinciali</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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